JAK/STAT Signalling: STAT Cannot Play with Ken and Barbie
نویسندگان
چکیده
منابع مشابه
JAK/STAT Signalling: STAT Cannot Play with Ken and Barbie
Transcriptional responses to the activation of a signalling pathway are cell-specific. New data show that the sequence-specific transcriptional repressors of the KEN/BCL-6 family play an important role in the selection of STAT targets in vertebrates and invertebrates, indicating that all STAT proteins may share this ancestral mechanism.
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A limited number of evolutionarily conserved signal transduction pathways are repeatedly reused during development to regulate a wide range of processes. Here we describe a new negative regulator of JAK/STAT signaling and identify a potential mechanism by which the pleiotropy of responses resulting from pathway activation is generated in vivo. As part of a genetic interaction screen, we have id...
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I think analogy is one of the core operations in human cognitive processing. There is evidence that the principles of Gentner‘s structure-mapping theory are applicable from mediumlevel vision to everyday reasoning to cognitive development to scientific discovery. That‘s quite a range of phenomena. Our computational modeling efforts do not yet span anything close to that range. But that‘s one of...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.01.021